发明名称 |
Methods and compositions for inhibiting the activation of thrombin-activatable fibrinolysis inhibitor (TAFI) |
摘要 |
Methods and products for the treatment of a disorder characterized by the cleavage of a C-terminal lysine or arginine from an intact peptide are provided. In the methods of the invention a peptide that inhibits the activation of thrombin-activatable fibrinolysis inhibitor (TAFI) is administered in an effective amount and in a pharmaceutically acceptable carrier to a subject having a disorder characterized by the cleavage of a C-terminal lysine or arginine from an intact peptide. The compositions are pharmaceutical compositions of peptides that inhibit the activation of TAFI. Also provided is a monoclonal antibody that binds TAFI zymogen but that does not bind to active TAFI and inhibits the activation of TAFI.
|
申请公布号 |
US5993815(A) |
申请公布日期 |
1999.11.30 |
申请号 |
US19970966432 |
申请日期 |
1997.11.07 |
申请人 |
UNIVERSITY OF VERMONT |
发明人 |
BAJZAR, LASZLO S.;NESHEIM, MICHAEL E.;CHURCH, WILLIAM R. |
分类号 |
A61P7/02;C07K16/40;(IPC1-7):A61K39/395 |
主分类号 |
A61P7/02 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|