摘要 |
PCT No. PCT/FI96/00560 Sec. 371 Date Sep. 16, 1998 Sec. 102(e) Date Sep. 16, 1998 PCT Filed Oct. 23, 1996 PCT Pub. No. WO97/15302 PCT Pub. Date May 1, 1997The levo-isomers of certain imidazole derivatives, particularly medetomidine, have been found to be inverse agonists of adrenergic alpha -2 receptors and are therefore useful in the prevention or treatment of conditions associated with overexpression or hypersensitization of the adrenergic alpha -2 receptors, such as obesity, a withdrawal symptom to an adrenergic alpha -2 receptor agonist, a neurological disorder, multiple system atrophy, diabetes mellitus, benign prostatic hyperplasia, and drug-induced sensitization of adrenergic alpha -2 receptors. The pharmaceutical composition is preferably transdermal.
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