发明名称 |
Dermal penetration enhancers and drug delivery systems involving same |
摘要 |
This transdermal drug delivery system comprises at least one physiologically active agent or prodrug thereof and at least one dermal penetration enhancer; characterised in that the dermal penetration enhancer is a safe skin-tolerant ester sunscreen. A non-occlusive, percutaneous or transdermal drug delivery system which comprises: (i) an effective amount of at least one physiologically active agent or prodrug thereof; (ii) at least one non-volatile dermal penetration enhancer; and (iii) at least one volatile liquid; characterised in that the dermal penetration enhancer is adapted to transport the physiologically active agent across a dermal surface or mucosal membrane of an animal, including a human, when the volatile liquid evaporates, to form a reservoir or depot of a mixture comprising the penetration enhancer and the physiologically active agent or prodrug within said surface or membrane; and the dermal penetration enhancer is of low toxicity to, and is tolerated by, the dermal surface or mucosal membrane of the animal.
|
申请公布号 |
NZ330942(A) |
申请公布日期 |
1999.11.29 |
申请号 |
NZ19970330942 |
申请日期 |
1997.02.19 |
申请人 |
MONASH UNIVERSITY |
发明人 |
REED, BARRY LEONARD;MORGAN, TIMOTHY MATTHIAS;FINNIN, BARRIE CHARLES |
分类号 |
A61K8/04;A61K8/368;A61K8/37;A61K8/44;A61K9/00;A61K9/12;A61K9/70;A61K31/24;A61K31/4178;A61K31/4196;A61K31/496;A61K31/704;A61K45/08;A61K47/14;A61L15/44;A61M16/06;A61M35/00;A61Q17/04;(IPC1-7):A61K7/42;A61K7/44 |
主分类号 |
A61K8/04 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|