发明名称 |
Improvements relating to encapsulation of bioactive agents |
摘要 |
Bioactive agent is encapsulated in a polymer microparticle in a (water-in-oil)-in-water emulsion-based method, and using a solvent that comprises ethyl acetate. Also described are microparticles comprising low inherent viscosity (i.v.) PLG, some with i.v. less than 0.5dl/g, and methods for their preparation. DNA release is modified through use of low i.v. PLG. A particle production method for scale-up uses a blender that avoids excessive shear damage to DNA being encapsulated. |
申请公布号 |
AU3938699(A) |
申请公布日期 |
1999.11.29 |
申请号 |
AU19990039386 |
申请日期 |
1999.05.07 |
申请人 |
MICROBIOLOGICAL RESEARCH AUTHORITY |
发明人 |
GRAHAM HENRY FARRAR;ANNE MARGARET TINSLEY-BOWN;DAVID HUGH JONES |
分类号 |
A61J1/05;A61K9/00;A61K9/16;A61K9/51;B01J13/00 |
主分类号 |
A61J1/05 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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