Indole derivatives as 5-ht2a ligands and as serotonine reuptake inhibitors

摘要

Pharmaceutical compounds of the formula: in which n is 1 to 6, m is 1 or 2 and p is 1 or 2, R<1> and R<2> are each hydrogen, C1-4 alkyl, C1-4 alkoxy, HO-C1-4 alkyl, C1-4 alkoxy-C1-4 alkyl, C1-4 alkylthio, halo, optionally substituted phenyl, optionally substituted phenyl-C1-4 alkyl, or R<1> and R<2> together with the carbon atom to which they are attached form a C3-6 cycloalkyl group, >C=O, C=NOR' where R' is hydrogen or C1-4 alkyl, R<3>, R<4> and R<5> are each hydrogen, halo, nitro, C1-4 alkyl, C1-4 alkoxy, C1-4 alkyl-CO-, where m is 0, 1 or 2, R'R"N-SO2-, -COOR', -CONR'R", -NR'R'', -N(OR')COOR'', -COR', -NHSO2R', where R' and R" are each hydrogen or C1-4 alkyl, R<6> and R<7> are each hydrogen or C1-4 alkyl, X is oxygen or sulphur, the dotted line represents an optional double bond, and the fluorine atom is attached at the 6- or 7-position; and salts thereof. Compounds (I) are active at the serotonin, 5-HT2A receptor.