Polymeric system for delivery of nucleic acid material to target cells in biological systems

摘要

A synthetic polymer-based carrier vehicle and a method of constructing the synthetic polymer-based carrier vehicle for delivery of nucleic acid material to target cells in biological systems are described. The method comprising the steps of: a) providing a cationic polyelectrolyte polymer material including a poly derivative of an amino acid or a synthetic amino acid; and b) bringing the nucleic acid material into association with said cationic polyelectrolyte polymer material to form by self-assembly therebetween a polyelectrolyte complex which provides a nucleic acid containing cationic polymer core for said carrier vehicle. The synthetic polymer-based carrier vehicle includes the amino acid derivative made by the method. The derivative is preferably a polyglutamine or polyasparagine derivative.