DERIVATIVES OF PIPERIDINE OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND INTERMEDIATE COMPOUNDS

摘要

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to derivatives of piperidine of the general formula (I) where each of R2,R means hydrogen atom or R - H and R - OH; R - phenyl, furyl, pyridyl, 1,3,4-oxadiazole-2-yl or 2-imidazolyl possibly substituted with halogen atom, hydroxy-, alkyl-, alkoxyl-group, COOR where R - alkyl, -CONR1R where R1,R - H, alkyl, S(O)nR where R - alkyl; n = 0, 1 or 2, or R and R in common with biradical X and carbon atom to which they bound can form spirocyclic ring - spiro(isobenzofuran-1[3H] -4'-piperirine or oxospiro-(isobenzofuran-1[3H]-4'-piperirine; R - H, or their pharmaceutically acceptable salts that show properties of NKA antagonist. EFFECT: improved method of synthesis, valuable pharmacological properties. 16 cl, 3 dwg, 28 ex