| 发明名称 |
FERMENTATIVE PREPARATION PROCESS FOR CYTOSTATICS AND CRYSTAL FORMS THEREOF |
| 摘要 |
The invention relates to a process for concentrating epothilones in culture media, a process for the production of epothilones, a process for separating epothilones A and B and a strain obtained by mutagenesis for the production of epothilones, as well as aspects related thereto. Crystal forms of epothilone B are also described. |
| 申请公布号 |
WO9942602(A3) |
申请公布日期 |
1999.11.25 |
| 申请号 |
WO1999EP01025 |
申请日期 |
1999.02.17 |
| 申请人 |
NOVARTIS AG;NOVARTIS-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH |
发明人 |
HOFMANN, HANS;MAHNKE, MARION;MEMMERT, KLAUS;PETERSEN, FRANK;SCHUPP, THOMAS;KUESTERS, ERNST;MUTZ, MICHAEL |
| 分类号 |
A61K31/427;A61P35/00;A61P35/04;A61P43/00;B01D15/08;C07D493/04;C12N1/14;C12P;C12P17/16;C12P17/18;C12R1/01;C12R1/645 |
主分类号 |
A61K31/427 |
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