| 摘要 |
The present invention describes compositions and methods for use when an org an is isolated from the circulatory system, i.e., in organ transplantation and surgery. The composition of the present invention uses an organ preservation or perfusion solution to which is added a Coenzyme Q10 in a solubilizing agent. The solubilizing agent of the present invention is capable of solubilizing Coenzyme Q10, is non-toxic to organ tissues and cells, and is compatible with organ perfusion devices. When used in an organ perfusion the compositions of the Coenzyme Q10 does not precipitate from the compositions of the present invention. Particularly, the solubilizing agents are polysorbate s, such as polysorbate-80 (polyoxyethylene (20) sorbitan mono-oleate) or phosphatides, such as lecithin, and the like. Methods are also provided for using the compositions of the present invention to protect organs from free radical damage, ischemia and perfusion injury during organ transplant and surgery.
|
