A process for preparing an optionally substituted 4-aminodiphenylamine comprising reacting an optionally substituted aniline and an optionally substituted nitrobenzene in the presence of water and a base while controlling the water content so as to ensure a molar ratio of water to the base charged of not less than about 4:1 at the start of the coupling reaction and not less than about 0.6:1 at the end of the coupling reaction to produce 4-nitrodiphenylamine and/or 4-nitrosodiphenylamine and/or salts thereof. The coupling reaction is followed by a hydrogenation reaction where the coupling reaction product is hydrogenated in the presence of a hydrogenation catalyst and added water so as to ensure a molar ratio of total water to base of at least about 4:1 at the end of hydrogenation. Aqueous and organic phases are obtained and the optionally substituted 4-aminodiphenylamine recovered from the organic phase.
申请公布号
WO9959956(A1)
申请公布日期
1999.11.25
申请号
WO1999US10743
申请日期
1999.05.14
申请人
FLEXSYS AMERICA L.P.
发明人
RAINS, ROGER, KERANEN;GENETTI, RALPH, ALBERT;LAMBERS, EDWARD, ALBERT;VAN HENGSTUM, ANTONIUS, JOHANNES