发明名称 |
LABELLED GLUTAMINE AND LYSINE ANALOGUES |
摘要 |
Synthetic analogues of lysine and glutamine are provided which function as substrates for the fibrin-stabilising enzyme Factor XIIIa even when labelled with a detectable moiety. The use of suitable protecting groups provides compounds which possess reduced susceptibility to in vivo metabolism especially by peptidases, and are hence useful agents for the diagnosis of thrombosis, embolism, atherosclerosis, inflammation or cancer.
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申请公布号 |
CA2332277(A1) |
申请公布日期 |
1999.11.25 |
申请号 |
CA19992332277 |
申请日期 |
1999.05.14 |
申请人 |
NYCOMED AMERSHAM PLC |
发明人 |
GUILBERT, BENEDICTE;WILSON, IAN ANDREW;GIBSON, ALEX;CHAMPION, SUSAN;STOREY, ANTHONY EAMON;MENDIZABAL, MARIVI;KNOX, PETER |
分类号 |
G01N33/60;A61K49/14;A61K51/08;A61P7/02;C07B59/00;C07K7/00;C07K14/00;C07K14/78;C07K14/81;(IPC1-7):C07K14/00 |
主分类号 |
G01N33/60 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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