A transgenic animal with alterations in an IRAK gene is prepared by introduction of an altered IRAK gene into a host animal. The resulting transgenic animals do not produce functional IRAK molecules. Cells and cell lines derived from these animals also contain the altered IRAK gene.
申请公布号
CA2328591(A1)
申请公布日期
1999.11.25
申请号
CA19992328591
申请日期
1999.05.13
申请人
ORTHO-MCNEIL PHARMACEUTICAL, INC.
发明人
LEUNG, WAI-PING;HARRIS, CRAFFORD A.;PETERSON, PER A.;SIEKIERKA, JOHN J.