The present invention relates to IL-6 antagonist peptides, isolated from a peptide library through the two-hybrids system by their ability to bind to the intracellular domain of gp130. Such peptides contain at least 5 amino acids and comprise an amino acid sequence as disclosed in SEQ.IDs.N.: 1-8. Substantially purified peptides are suitable for use in pharmaceutical compositions as active ingredients in pathologies that require IL-6 activity inhibition.
申请公布号
CA2332817(A1)
申请公布日期
1999.11.25
申请号
CA19992332817
申请日期
1999.05.18
申请人
APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.
发明人
SERLUPI-CRESCENZI, OTTAVIANO;PEZZOTTI, ANNA RITA;DELLA PIETRA, LINDA;BRESSAN, ALESSANDRO