| 摘要 |
Monoclonal antibodies (in particular, P2L-1Ca) against 19P2 ligand having an extremely high avidity and being capable of neutralizing the arachidonic aci d metabolite-releasing activity of the 19P2 ligand. Thus, these antibodies are usable in diagnostics, preventives, remedies, etc. for various diseases in association with abnormalities in the pituitary function regulatory mechanis m (for example, promotion of the prolactin secretion), the central nerve regulatory mechanism, the pancreatic function regulatory mechanism, etc. The 19P2 ligand or its derivatives can be specifically quantitated at a high sensitivity by an immunoassay method based on the sandwich method with the u se of the above-mentioned monoclonal antibodies (in particular, the sandwich method with the use of the monoclonal antibody together with an antibody recognizing the intermediate part of the 19P2 ligand). This quantitating method is usable in clarifying the physiological functions of the 19P2 ligan d or its derivative.
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