Tetrahydronaphthalin-Peptidderivate

摘要

Tetrahydronaphthalene derivatives of the general formulae and wherein R<1> is hydrogen, bromine, cyano, formyl, hydroxyl, lower alkyl, lower alkenyl, lower alkynyl, lower alkoxy, aryloxy, lower aralkoxy or aryl; R<2> is an optionally protected chain of up to 20 amino acid esters, whose C-terminal amino acid can be present as a free or protected acid or in the form of an amide; A<1>, A<2>, A<3> and A<4> are each radicals of alpha -amino acids whose alpha -C atom, when it is unsymmetrical, is present in A<1> and A<2> in the L configuration and in A<3> and A<4> in the D configuration; X is oxygen or sulphur; and Y, together with the two C atoms, is an optionally substituted benzene, furan, thiophene, pyridine or pyrimidine ring; and salts thereof, in particular those which contain no protective group(s), are useful aids to determine biologically active peptide sequences and are thus so-called "research tools"; they are, however, also potentially suitable as medicines.