| 摘要 |
<p>PROBLEM TO BE SOLVED: To improve the isomerization process, in other words, racemization and epimerization for optically active amino acids, typically alanine,α- aminobutanoic acid, valine, leucine, isoleucine, phenylalanine, tryptophane and methionine, in the presence of a lower fatty acid and an aldehyde and provide an high-efficiency isomerization process for amino acids with lowered energy consumption and easy recycle of the lower fatty acid and aldehyde as the isomerization catalyst. SOLUTION: An optically active amino acid is dispersed in an inert solvent that substantially does not dissolve amino acids, preferably an aromatic hydrocarbon such as benzene, toluene, xylene or halogenated benzene. A lower fatty acid, preferably a 1-5C saturated fatty acid as acetic acid, propionic acid or butanoic acid and an aliphatic aldehyde or an aromatic aldehyde, preferably an aromatic aldehyde such as benzaldehyde or salicylaldehyde are allowed to act on the dispersion to effect the isomerization. The mixture of the optical isomers of the crystallized amino acid separating from the solvent are collected by the solid-liquid phase separation.</p> |
