| 摘要 |
A 1.alpha.,24-(OH)2-V.D3 cream composition comprising (a) a therapeutically effective amount of 1.alpha.,24-(OH)2-V.D3, (b) an oil phase component including (i) a solid oil component composed of 5 to 20 parts by weight of white petrolatum and 5 to 15 parts by weight of higher alcohols and (ii) a liquid oil component comprising of 3 to parts by weight of squalane, (c) an aqueous phase component, and (d) 2.5 to 7.5 parts by weight at least two surfactants, wherein the 1.alpha.,24-(OH)2-V.D3 cream composition has a weight ratio of the solid oil component to the liquid oil component (i.e., solid oil component/liquid oil component) of at least approximately 2, the higher alcohols are composed of stearyl alcohol and cetyl alcohol, the weight ratio of the stearyl alcohol to the higher alcohols (i.e., stearyl alcohol/higher alcohols) is approximately 0.65 to approximately 0.9, at least 50% by weight of the surfactants is at least one surfactant having an HLB value of approximately 5 or less, and the HLB value of the surfactants as a whole is approximately 8 to approximately 18.
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