发明名称 |
Cross-linked cellulose as a tablet excipient |
摘要 |
Cross-linked cellulose is an excellent binder disintegrant that can be used in the preparation of pharmaceutical tablets. The tablets that are so prepared are made of a compressed mixture of a powder of a pharmaceutically active ingredient with a powder of a pharmaceutical excipient including a pharmaceutically acceptable form of cross-linked cellulose in an amount up to 35% by weight with respect to the total weight of the tablet. The cross-linked cellulose is prepared by cross-linking microcrystalline or fibrous cellulose with a cross-linking agent such as epichlorhydrin in a relative amount of 2 to 50 g of cross-linking agent per 100 g of cellulose. Tests have proved that cross-linked cellulose is very easy to synthetise and has excellent binding/disintegrating properties that are function of the cross-linking degree. At low cross-linking degree, cross-linked cellulose is more a binder than a disintegrant whereas at high cross-linking degree, it is more a disintegrant than a binder.
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申请公布号 |
US5989589(A) |
申请公布日期 |
1999.11.23 |
申请号 |
US19970956117 |
申请日期 |
1997.10.24 |
申请人 |
CARTILIER, LOUIS;CHEBLI, CHAFIC |
发明人 |
CARTILIER, LOUIS;CHEBLI, CHAFIC |
分类号 |
A61K9/20;(IPC1-7):A61K9/22 |
主分类号 |
A61K9/20 |
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地址 |
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