发明名称 3-oxiranyl benzoic acids and derivatives thereof
摘要 The present invention relates to compounds of the formula or a pharmaceutically acceptable salt thereof wherein R is alkyl of 12 carbon atoms, alkenyl of 12 carbon atoms having from 1 to 4 -CH=CH- groups when the carbon adjacent to R is saturated and from 1 to 2 -CH=CH- groups when the carbon adjacent to R is unsaturated, aryl, heterocyclo, alkoxyalkyl wherein the alkyl groups have 1 to 6 carbon atoms, or aryloxyalkyl wherein the alkyl group has 1 to 6 carbon atoms R1 is hydrogen, lower alkyl, or a pharmaceutically acceptable cation. These compounds are inhibitors of leukotriene A4(LTA4) hydrolase.
申请公布号 US5990326(A) 申请公布日期 1999.11.23
申请号 US19920976614 申请日期 1992.11.16
申请人 G.D. SEARLE & CO. 发明人 DJURIC, STEVAN WAKEFIELD;PENNING, THOMAS DALE
分类号 A61K31/335;A61K31/336;A61P19/06;A61P29/00;C07D303/38;C07D303/40;(IPC1-7):C07D303/16 主分类号 A61K31/335
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