| 发明名称 |
Tri-hydroxymethyl-amino methane-gluconate dihydroxy-aluminate prepn. - by reacting gluconic acid with aluminium isopropylate and gluconate with tri-hydroxymethyl aminomethane |
| 摘要 |
<p>Industrial-scale prpn. of tris(hydroxymethyl) amino methane-gluconate-dihydroxy-aluminate having formula (HO)2Al-O-CH2-(CHOH)4-COOH.NH2 (CH2OH)3 (I) takes place in 2 steps. (1) reaction of D-gluconic acid with Al isopropylate, pref. with stirring at 30-80 (60-70) degrees C and (2) reaction of Al gluconate obtd. with tri-hydroxymethyl aminomethane. (I) has acid-inhibiting activity, high neutralising effect and buffer activity.</p> |
| 申请公布号 |
DE2518584(A1) |
申请公布日期 |
1976.11.04 |
| 申请号 |
DE19752518584 |
申请日期 |
1975.04.25 |
| 申请人 |
SCHARPER S.P.A. PER L'INDUSTRIA FARMACEUTICA |
发明人 |
FAZZINI,MASSIMO |
| 分类号 |
C07C51/41;C07F5/06;(IPC1-7):07C59/17;07C91/10 |
主分类号 |
C07C51/41 |
| 代理机构 |
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