Chimeric receptors

摘要

DNA is described which codes for chimeric receptors which contain two or more independent polypeptide chains each of which contains an extra cellular ligand association domain attached to a signalling domain through a transmembrane and optionally one or more spacer domains. Each polypeptide chain can be expressed in an effector cell and will remain largely unassociated with the other(s) in the absence of ligand. The presence of ligand induces a stable interaction between the ligand association domains of each chain and facilitates interaction between the intracellular domains leading to a signalling event and activation of the cell. The activated cell may be of use in medicine for example in the treatment of diseases such as cancer.