Process for the preparation of 4-amino- DELTA 4-3-ketosteroids via 4-nitro- DELTA 4-3-ketosteroids

摘要

The present invention provides 4-nitro- DELTA 4-3-ketosteroids, their use as steroid C17-20 lyase and 5 alpha -reductase inhibitors and to a novel process for preparing a compound of the formula: comprising sequentially: a) reacting a starting compound of the formula with an effective amount of a strong base at an elevated or suitable temperature for a time sufficient to create the corresponding thermodynamic dienolate, followed by addition of a neutral nitrating agent to produce the 4-nitrosteroid; and then; b) reacting the 4-nitrosteroid with a suitable reducing agent.