发明名称 |
Method for producing antithrombin-III, method for purifying it, and preparation containing it |
摘要 |
A method for producing antithrombin-III from an antithrombin-III-containing aqueous solution, comprising at least one of the following steps (a) and (b): (a) heating the antithrombin-III-containing aqueous solution in the presence of a stabilizing agent so that 85% or more of the activity of antithrombin-III before the heating is maintained after the heating, and that the ratio of an antithrombin-III monomer after the heating is maintained at 95% or more; and (b) treating the antithrombin-III-containing aqueous solution with a metal chelate resin and recovering a purified antithrombin-III.
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申请公布号 |
US5989593(A) |
申请公布日期 |
1999.11.23 |
申请号 |
US19970974191 |
申请日期 |
1997.11.19 |
申请人 |
YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. |
发明人 |
IDENO, SHOUJI;URIYU, KATSUHIRO;UEMURA, YAHIRO |
分类号 |
A61K38/00;C07K14/81;(IPC1-7):A61K35/14;A61K38/16 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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