| 发明名称 |
Pertussis toxoid made by reacting pertussis toxin with the nitrating agent TNM |
| 摘要 |
A toxoid of pertussis toxin in which the pertussis toxin is modified essentially only at one or more tyrosine residues, as by the use of a nitrating agent such as tetranitromethane or by recombinant DNA techniques; a vaccine including the toxoid; and methods of preparing the toxoid and the vaccine.
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| 申请公布号 |
US5989564(A) |
申请公布日期 |
1999.11.23 |
| 申请号 |
US19910759822 |
申请日期 |
1991.09.12 |
| 申请人 |
MASSACHUSETTS HEALTH AND RESEARCH INSTITUTE |
发明人 |
WINBERRY, LARRY K. |
| 分类号 |
C12N1/21;A61K38/00;A61K39/00;A61K39/10;A61P31/04;A61P37/00;C07K1/107;C07K1/113;C07K1/22;C07K14/195;C07K14/235;C07K14/41;C12N15/00;C12N15/31;C12P21/02;C12R1/19;(IPC1-7):A61K39/10;A61K39/02 |
主分类号 |
C12N1/21 |
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