发明名称 |
Resistance to viruses and viroids in transgenic plants and animals expressing dsRNA-binding protein |
摘要 |
The invention provides a method for imparting resistance in animals to viruses, and in plants to viruses and viroids, that express double-stranded RNA-like structures (dsRNAs). This method enables the binding of pathogenic dsRNAs during the infection process by expression of dsRNA-binding protein in transgenic animal and plant hosts, thus interrupting the infection cycle and inhibiting disease. The presence of a dsRNA-binding protein in a transgenic host renders the transgenic host resistant to the phenotypic symptoms of viral infection and/or decreased pathogen replication. Accordingly, the present invention provides a genetically engineered animal and plant, stably transformed to express a dsRNA-binding protein, such that the transgenic host displays resistance to virus and/or viroid challenge.
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申请公布号 |
US5990388(A) |
申请公布日期 |
1999.11.23 |
申请号 |
US19950482286 |
申请日期 |
1995.06.07 |
申请人 |
RESEARCH CORPORATION TECHNOLOGIES, INC. |
发明人 |
ROTH, DON ALLEN;LANGLAND, JEFFREY OLAF |
分类号 |
C12N15/09;A01H5/00;A61K35/76;A61K38/00;A61K48/00;A61P31/12;A61P43/00;C07K14/07;C07K14/14;C12N5/10;C12N7/00;C12N15/34;C12N15/82;C12N15/85;(IPC1-7):C12N5/00;C12N15/00;A01H1/04 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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