Citotoksiski 2-okso-1azetidiniletikskabes esteru atvasinajumi

摘要

The present invention pertains to the pharmacologically active substances, particularly to cytotoxically agents for chemotherapy for cancer. The said compounds contain modifying azetidin-2-one having specifically selected substituents in the positions 1, 3 and 4. According results of experiments the invented substances have cytotoxically quality in vitro on cell-lines HT 1080, MG-22A and B 16: by using 0.25-10 mg/ml concentrations of said substance is observable death of 50 % cells. Direct correlation between cytotoxically activity of studied compounds and their ability to induce biosynthesis of NO in cells is observed. Compounds having expressed cytotoxically activities compare with compounds having low activity have considerably extent the mentioned ability to induce biosynthesis.