PROCESS FOR PREPARATION OF 4,5-EPOXYMORPHINAN-6-OXYGLUCURONIDES
摘要
Conjugation of 4,5-Epoxymorphinan-6-ols with Bromoglucuronides in the presence of Zinc containing compounds as activator under conditions capable of forming 4,5-Epoxymorphinan-6-oxyglucuronides is disclosed. This novel approach provides an efficient method for preparation of both anomers of 4,5-Epoxymorphinan-6-oxyglucuronides. The deprotected end products are useful as analgesic agents.
申请公布号
WO9958545(A1)
申请公布日期
1999.11.18
申请号
WO1999GB01508
申请日期
1999.05.12
申请人
CENES LIMITED;GUTMAN, ARIE, L.;NISNEVITCH, GENADI;YUDOVITCH, LEV;ROKHMAN, IGOR
发明人
GUTMAN, ARIE, L.;NISNEVITCH, GENADI;YUDOVITCH, LEV;ROKHMAN, IGOR
