发明名称 |
POLYMERIC SYSTEM FOR DELIVERY OF NUCLEIC ACID MATERIAL TO TARGET CELLS IN BIOLOGICAL SYSTEMS |
摘要 |
A synthetic polymer-based carrier vehicle and a method of constructing the synthetic polymer-based carrier vehicle for delivery of nucleic acid material to target cells in biological systems are described. The method comprising the steps of: a) providing a cationic polyelectrolyte polymer material including a (I) derivative of an amino acid or a synthetic amino acid, or a vinyl-type polymer; and b) bringing the nucleic acid material into association with said cationic polyelectrolyte polymer material to form by self-assembly therebetween a polyelectrolyte complex which provides a nucleic acid containing cationic polymer core for said carrier vehicle. The synthetic polymer-based carrier vehicle includes the amino acid derivative or the vinyl type polymer made by the method. The derivative is preferably a polyglutamine or polyasparagine derivative. |
申请公布号 |
CA2331840(A1) |
申请公布日期 |
1999.11.18 |
申请号 |
CA19992331840 |
申请日期 |
1999.05.07 |
申请人 |
UNIVERSITEIT GENT |
发明人 |
DEKIE, LUC;SCHACHT, ETIENNE HONORE |
分类号 |
A61K47/48;A61K48/00 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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