| 发明名称 |
PROCESS FOR PREPARATION OF 4,5-EPOXYMORPHINAN-6-OXYGLUCURONIDES |
| 摘要 |
Conjugation of 4,5-Epoxymorphinan-6-ols with Bromoglucuronides in the presen ce of Zinc containing compounds as activator under conditions capable of formin g 4,5-Epoxymorphinan-6-oxyglucuronides is disclosed. This novel approach provides an efficient method for preparation of both anomers of 4,5- Epoxymorphinan-6-oxyglucuronides. The deprotected end products are useful as analgesic agents.
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| 申请公布号 |
CA2331866(A1) |
申请公布日期 |
1999.11.18 |
| 申请号 |
CA19992331866 |
申请日期 |
1999.05.12 |
| 申请人 |
CENES LIMITED |
发明人 |
YUDOVITCH, LEV;ROKHMAN, IGOR;GUTMAN, ARIE L.;NISNEVITCH, GENADI |
| 分类号 |
C07H17/04;A61K31/7042;A61K31/7048;A61K31/706;A61P25/04;C07H17/08;(IPC1-7):C07H17/00 |
主分类号 |
C07H17/04 |
| 代理机构 |
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