SUSTAINED DNA DELIVERY FROM STRUCTURAL MATRICES

摘要

Disclosed are particular 3-dimensional structural matrices containing DNA and their use in the prolonged release of DNA in various biological environments. The DNA-matrix materials are created such that they maintain a defined space, allowing cellular migration, transfection and proliferation to occur in a controlled manner. Such DNA-containing structural matrices are thus particularly useful in in vivo cell transfection and gene expression in the context of gene therapy.