| 摘要 |
The invention provides compounds of formula (I) having a structure wherein A is hydrogen, halogen, or OH; B and D are each, independently, hydrogen, halogen, CN, alkyl of 1-6 carbon atoms, aryl, aralkyl of 6-12 carbon atoms, nitro, amino or OR; R is hydrogen, alkyl of 1-6 carbon atoms, -COR<1>, -CH2CO2R<1>, -CH(R<1a>)CO2R<1>, or -SO2R<1>; R<1> and R<1a> are each, independently, hydrogen, alkyl of 1-6 carbon atoms, aralkyl of 6-12 carbon atoms or aryl; E is S, SO, SO2, O; X is hydrogen, halogen, alkyl of 1-6 carbon atoms, CN, perfluoroalkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, aryloxy, arylalkoxy of 6-12 carbon atoms, nitro, amino, alkylsulfanyl of 1-6 carbon atoms, arylsulfanyl, pyridylsulfanyl, 2-N,N-dimethylaminoethylsulfanyl, or -OCH2CO2R<1b>; R<1b> is hydrogen or alkyl of 1-6 carbon atoms; Y and Z are each, independently, hydrogen or OR<2>; R<2> is hydrogen, alkyl of 1-6 carbon atoms, aralkyl of 6-12 carbon atoms, or -CH2CO2R<3>; R<3> is hydrogen or alkyl of 1-6 carbon atoms; C is hydrogen, halogen or OR<4>; R<4> is hydrogen, alkyl of 1-6 carbon atoms, -CH(R<5>)W, -C(CH3)2CO2R<6>, 5-thiazolidine-2,4-dione, -CH(R<7>)CH2CO2R<6>, -COR<6>, PO3(R<6>)2, or -SO2R<6>; R<5> is hydrogen, alkyl of 1-6 carbon atoms, aralkyl, aryl, CH2(1H-imidazol-4-yl), -CH2(3-1H-indolyl), -CH2CH2(1,3-dioxo-1,3-dihydro-isoindol-2-yl), -CH2CH2(1-oxo-1,3-dihydro-isoindol-2-yl), -CH2(3-pyridyl), or -CH2CO2H; W is -CO2R<6>, -CONH2, -CONHOH, CN, -CONH(CH2)2CN, 5-tetrazole, -PO3(R<6>)2, -CH2OH, or -CH2Br, -CONR<6>CHR<7>CO2R<8>, R<6> is hydrogen, alkyl of 1-6 carbon atoms, aryl or aralkyl; R<7> is hydrogen, alkyl of 1-6 carbon atoms, aryl or aralkyl; R<8> is hydrogen, alkyl of 1-6 carbon atoms, aryl or aralkyl; or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insuling resistance or hyperglycemia. |
