| 发明名称 |
RECOMBINANT (ALPHA)-L-IDURONIDASE, METHODS FOR PRODUCING AND PURIFYING THE SAME AND METHODS FOR TREATING DISEASES CAUSED BY DEFICIENCIES THEREOF |
| 摘要 |
The present invention provides a recombinant .alpha.-L-iduronidase and biologically active fragments and mutants thereof, methods to produce and purify this enzyme as well as methods to treat certain genetic disorders including .alpha.-L-iduronidase deficiency and mucopolysaccharidosis I (MPS I).
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| 申请公布号 |
CA2328518(A1) |
申请公布日期 |
1999.11.18 |
| 申请号 |
CA19992328518 |
申请日期 |
1999.05.07 |
| 申请人 |
HARBOR-UCLA |
发明人 |
TANAMACHI, BECKY;KAKKIS, EMIL D. |
| 分类号 |
C12N15/09;A61K38/00;A61K38/46;A61K48/00;A61P43/00;C12N1/04;C12N5/10;C12N9/24;C12N15/56;C12R1/91;(IPC1-7):C12N15/56;C12N5/00;A61K38/47;C12N15/85 |
主分类号 |
C12N15/09 |
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