REGULATION OF GLYCOSAMINOGLYCAN SYNTHESIS, METHODS AND REAGENTS RELATED THERETO

摘要

The present invention concerns the discovery of a new family of hedgehog interacting proteins, referred to herein as "hedgegehog interacting proteins" or "Exts", which are demonstrated to bind to hedgehog polypeptides with high affinity. As described herein, the Ext proteins are required for and as such regulate hedgehog diffusion.