CARBAPENEM DERIVATIVES, UTILIZATION THEREOF AND INTERMEDIATE COMPOUNDS OF THE SAME

摘要

Carbapenem compounds represented by general formula (I) wherein R<1> represents a modifying group hydrolyzable in vivo; R<2> and R<3> may be the same or different and each represents lower alkyl; and R represents a group represented by formula (B) or formula (C) (wherein R<4> and R<5> may be the same or different and each represents hydrogen or lower alkyl; and R<6> represents C1-10 alkyl). When administered orally, the compounds (I) are excellent in the absorbability via the digestive tract and exhibit sufficient antibacterial effects over a broad scope of bacterial species. Thus, they are highly useful as preventives/remedies for infectious diseases, in particular, microbisms.