摘要 |
NEW MATERIAL:N-(carboxyethyl) adenosine triphosphate of the formula. USE:Enzyme assistant substrates (coacters) for industrial utilization of ligands or enzymes for affinity chromatography, having a great substrate activity with a retained activity of ATP, low cost and improved practicality. Useful for kinase, dehydrogenase, particularly acetate kinase. PROCESS:ATP dissolved in water is reacted with a halopropionic acid, e.g. iodo- or bromopropionic acid, or beta-propiolactone to give 1-carboxyethyl ATP, which is subjected to the Dimroth rearrangement to give the compound of the formula. |