发明名称 |
MMP-9 GENE POLYMORPHISMS |
摘要 |
A method of diagnosis or prognosis of a disease or characterisation of a genotype or genetic sequence which method comprises providing a nucleic acid sample and determining the nature of one or more genetic variants of an MMP-9 gene. Also described are oligonucleotides which hybridise to variants of a polymorphic sequence in the MMP-9 gene or its reverse complement. The method and oligonucleotides are of particular use for the diagnosis and prognosis of diseases characterised by metalloproteinase mediated remodelling, such as atherosclerosis, tumour invasion and metastasis, or inflammatory disease. |
申请公布号 |
CA2327538(A1) |
申请公布日期 |
1999.11.11 |
申请号 |
CA19992327538 |
申请日期 |
1999.05.07 |
申请人 |
ISIS INNOVATION LIMITED |
发明人 |
HENNEY, ADRIANO;YE, SHU;ZHANG, BAI, PING |
分类号 |
C12Q1/68;(IPC1-7):C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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