Mikrobielle Herstellung von Substanzen aus dem aromatischen Stoffwechsel / III

摘要

The invention relates to a process for microbially preparing substances from aromatic metabolism, in particular aromatic amino acids. In addition, the invention relates to gene structures and transformed cells. According to the invention, an increase in the production of substances, in particular aromatic amino acids, is observed by introducing or increasing the activity of a glucose dehydrogenase. Increasing the activity of a glucose-oxidizing enzyme leads to the intracellular formation of gluconolactone and gluconic acid from glucose-containing substrates. In a preferred embodiment, the glucose dehydrogenase is derived from Bacillus megaterium. The process according to the invention can be used to provide a wider spectrum of substances.