发明名称 |
RECOMBINANT VIRUS EXPRESSING FOREIGN DNA ENCODING FELINE CD80, FELINE CTLA-4 OR FELINE CD86 AND USES THEREOF |
摘要 |
The present invention involves a recombinant virus which comprises at least one foreign nucleic acid inserted within a non-essential region of the viral genome of a virus, wherein each such foreign nucleic acid encodes a protein. The protein which is encoded is selected from the groups consisting of a feline CD28 protein or an immunogenic portion thereof, a feline CD80 protein or an immunogenic portion thereof, a feline CD86 protein or an immunogenic portion thereof, or a feline CTLA-4 protein or an immunogenic portion thereof. The protein is capable of being expressed when the recombinant virus is introduced into an appropriate host. The present invention also involves a recombinant virus further comprising a foreign nucleic acid encoding an immunogen derived from a pathogen. The present invention also comprises recombinant viruses which are capable of enhancing an immune response in a feline. The present invention also comprises recombinant viruses which are capable of suppressing an immune response in a feline.
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申请公布号 |
CA2327528(A1) |
申请公布日期 |
1999.11.11 |
申请号 |
CA19992327528 |
申请日期 |
1999.04.30 |
申请人 |
SCHERING-PLOUGH LTD. |
发明人 |
COCHRAN, MARK D.;WINSLOW, BARBARA J. |
分类号 |
C12N15/09;A61K38/00;A61K39/12;A61K39/125;A61K39/15;A61K39/215;A61K39/23;A61K39/245;A61K48/00;A61P31/12;A61P37/06;A61P43/00;C07K14/705;C12N7/00;C12N15/12;C12N15/86;C12N15/863;C12N15/869;(IPC1-7):C12N15/86;C12N7/01;A61K39/02;C12N15/11 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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