| 摘要 |
A sugar composition for tableting by direct compression comprises a minor fraction, preferably 10-35%, of particulate trehalose in combination with a major fraction of one or more substances, such as sugars other than trehalose, that are not directly compressible to form tablets having high integrity. The tablets may be used as a confectionary item or as a drug. The sugar may be one or more of sucrose, glucose (dextrose), fructose, lactose, maltose and sugar alcohols but is preferably sucrose. Preferably the one or more sugars other than trehalose make up from 50-98 % of the composition and in combination with trehalose make up at least 90% of the composition. The composition is preferably free of binders or granulating agents but may comprise 0.1-10% of a flavouring agent, such as a non-sugar sweetener, and/or comprise 0.1-10% of a medicinal substance. A preferred method of manufacture of the sugar composition comprises spray drying of the constituents or coating trehalose onto the major constituents followed by compression at 40-200 Mpa to give tablets with a crushing strength of at least 2 Kp (Kg force). |
