发明名称 |
Thermostabilization, osmoprotection, and protection against desiccation of enzymes, cell components and cells by mannosyl-glycerate |
摘要 |
The utilization of mannosylglycerate as a stabilizer of enzymes and other cell components or cells, namely against heat, freezing, desiccation, lyophilization or repeated usage, is disclosed. Examples with lactate dehydrogenase and alcohol dehydrogenase show that this compound is a better protecting agent than trehalose. This solute is produced in the hyperthermophilic archaea Pyrococcus furiosus, species of the genera Methanothermus and Thermococcus, and in the thermophilic bacteria Rhodothermus marinus and Thermus thermophilus. A purification procedure is disclosed. <IMAGE> |
申请公布号 |
EP0816509(A3) |
申请公布日期 |
1999.11.10 |
申请号 |
EP19970670002 |
申请日期 |
1997.03.14 |
申请人 |
IBET - INSTITUTO DE BIOLOGIA EXPERIMENTAL E TECNOLOGICA |
发明人 |
SANTOS, MARIA HELENA DIAS;MARTINS, ANA ALEXANDRA;COSTA, MILTON |
分类号 |
C07K1/14;C12N1/04;C12N9/04;C12N9/96;C12P19/44 |
主分类号 |
C07K1/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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