ANALOGS OF GAMMA-AMINOBUTYRIC ACID, METHOD OF THEIR SYNTHESIS, METHOD OF TREATMENT AND PHARMACEUTICAL COMPOSITION

摘要

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to compounds that are analogs of gamma-aminobutyric acid. Invention describes new derivatives of gamma-aminobutyric acid of the general formula (I): gamma where R is a direct or branched alkyl group containing 2-6 carbon atoms; H2NCH(R3)-C(R1)(R2)-CH2COOH and R2 - hydrogen atom, and their individual enantiomers and pharmaceutically acceptable salts. Invention describes also a method of synthesis of the above indicated compounds, a method of treatment and a pharmaceutical composition based on the above indicated compounds. The synthesized compounds can be used as agents in an antiseizure therapy, disorders of the central nervous system. EFFECT: improved method of synthesis, enhanced curative effectiveness of compounds. 15 cl, 6 tbl, 3 dwg, 3 ex