Azole derivative with leukotriene (LTs) antagonizing activity and thromboxane (TX) A2 antagonizing activity

摘要

PCT No. PCT/JP95/02085 Sec. 371 Date Aug. 15, 1997 Sec. 102(e) Date Aug. 15, 1997 PCT Filed Oct. 12, 1995 PCT Pub. No. WO96/11916 PCT Pub. Date Apr. 25, 1996An azole derivative represented by general formula (I) or a pharmaceutically acceptable salt thereof, having both of a leukotriene antagonistic effect and a thromboxane A2 antagonistic effect and being useful in preventing or treating allergic diseases, ischemic heart diseases or ischemic brain diseases, and a medicinal composition containing the same as the active ingredient, wherein R1 and R2 may be the same or different and represent each hydrogen, cycloalkyl, etc., or R1 and R2 together with (a) may form a fused ring (b) or (c) which may be substituted by optionally substituted lower alkyl, amino, etc.; R3, R6, R7, R8 may be the same or different and represent each hydrogen, amino, etc.; R4 represents cyano, tetrazolyl, -COOR9, etc.; R5 represents hydrogen or lower alkyl; D represents optionally substituted lower alkylene; X and Z may be the same or different and represent each oxygen or sulfur; Y represents -N= or -CH=; A represents -O-B-, -B-O-, -S-B-, -B-S- or -B- (B being lower alkylene or lower alkenylene); and n is 0, 1, or 2.