| 摘要 |
PURPOSE:The reaction between a corresponding halogenated starting compound and an alcohol is carried out in an easy-to-handle combination of aqueous alkali and a hydrophobic organic solvent in the presence of a salt containing a quaternary ammonium ion to permit quantitative production of the titled compound in a short time. CONSTITUTION:The reaction between 2-halogeno-N-(2-diethylaminoethyl)-coinchonic acid amide of formula II (X is halogen) and n-butanol is conducted in a combination of an aqueous alkali such as sodium hydroxide or potassium hydroxide and a hydrophobic organic solvent such as benzene or toluene in the presence of a salt containing a quaternary ammonium ion of formula I (R1-R4 are 1-20C alkyl, arylalkyl) such as tetramethylammonium, benzyltriethylammonium bromide to give 2-butoxy-N-(2-diethylaminoethyl)cinchonic acid amide of formula III. USE:Its hydrochloride is used as a local anesthesis. |
