| 摘要 |
NEW MATERIAL:A compound shown by the formula I (A is H or hydroxyl group; each hydroxyl group may be protected) or its salt. EXAMPLE:N-[( 1R,2S )-( 2,4/3,5 )-2,3,4-Trihydroxy-5-hydroxymethylcyclohexyl]validamine. USE:Useful for preventing hyperglycemia and various kinds of diseases (e.g., corpulence, etc.) caused by hyperglycoplasmia, and a feed additive for animals. Having alpha-glucosidase inhibitory activity. Stable crystal or powder having almost no toxicity. PROCESS:A compound shown by the formula II is condensed with a cyclic ketone shown by the formula III in a solvent such as methanol, etc. to give a Schiff base, which is reduced with a reducing agent such as sodium boron hydride, etc. at room temperature - about 100 deg.C, to give a compound shown by the formula I . |
