发明名称 |
5-aminoindeno(1,2-c)pyrazol-4-ones as anti-cancer and anti-proliferative agents |
摘要 |
The present invention relates to the synthesis of a new class of indeno[1,2-c]pyrazol-4-ones of formula (I):that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-7 and their regulatory subunits know as cyclins A-G. This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents. |
申请公布号 |
AU3654899(A) |
申请公布日期 |
1999.11.08 |
申请号 |
AU19990036548 |
申请日期 |
1999.04.20 |
申请人 |
DU PONT PHARMACEUTICALS COMPANY |
发明人 |
DAVID A. NUGIEL;DAVID J. CARINI;EDDY W. YUE;SUSAN V. DIMEO |
分类号 |
A61K31/416;A61K31/422;A61K31/427;A61K31/4427;A61K31/443;A61K31/4433;A61K31/4439;A61K31/454;A61K31/4725;A61K31/496;A61K31/5377;A61K31/541;A61P35/00;A61P43/00;C07D231/54;C07D401/04;C07D401/12;C07D401/14;C07D403/04;C07D403/12;C07D403/14;C07D405/04;C07D405/12;C07D405/14;C07D409/04;C07D409/12;C07D409/14;C07D413/04;C07D413/14;C07D417/04;C07D417/12;C07D417/14 |
主分类号 |
A61K31/416 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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