Parainfluenza virus glycoproteins and vaccines

摘要

PCT No. PCT/CA96/00639 Sec. 371 Date Aug. 7, 1998 Sec. 102(e) Date Aug. 7, 1998 PCT Filed Sep. 23, 1996 PCT Pub. No. WO97/11093 PCT Pub. Date Mar. 27, 1997In summary of this disclosure, the present invention provides hemagglutinin-neuraminidase (HN) and Fusion (F) glycoproteins isolated and purified from parainfluenza viruses types 1, 2 and 3, methods of producing the same, and uses thereof in immunogenic compositions and diagnostic embodiments. In particular, a trivalent vaccine containing HN and F glycoproteins from PIV-1, PIV-2 and PIV-3 generated an immune response capable of neutralizing each of the virus types. Modifications are possible within the scope of the invention.