PEG-LHRH analog conjugates, where a PEG moiety is covalently bound to a serine residue of a LHRH analog either directly or via a bifunctional linker molecule, such as an amino acid, and methods for producing these conjugates are provided in the present invention. Also provided are a pharmaceutical composition and a method for treating pathologies in which LHRH analog administration is beneficial.
申请公布号
WO9955376(A1)
申请公布日期
1999.11.04
申请号
WO1999US09160
申请日期
1999.04.28
申请人
APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.;EL TAYAR, NABIL;ZHAO, XUAN;BENTLEY, MICHAEL, D.
