发明名称 |
ADENOVIRAL VECTORS WITH MODIFIED CAPSID PROTEINS |
摘要 |
The present invention is directed to adenoviral vectors having modified capsid proteins which comprise heterologous ligands that improve and/or alter the infectious capability of the vector. Such ligands are capable of binding to target cells, and their inclusion into adenoviral vectors facilitates the binding and infectious properties of the vectors. In a preferred embodiment, the ligands are peptides, and the target cells are epithelial cells. The invention is also directed to novel heterologous ligands, to ligand-receptor complexes, and to compositions comprising the adenoviral vectors of the invention. Additional aspects of the invention include methods to use the adenoviral vectors of the invention to deliver transgenes to target cells. |
申请公布号 |
WO9936545(A3) |
申请公布日期 |
1999.11.04 |
申请号 |
WO1999US00913 |
申请日期 |
1999.01.15 |
申请人 |
GENZYME CORPORATION;ROMANCZUK, HELEN;ARMENTANO, DONNA;O'RIORDAN, CATHERINE, R. |
发明人 |
ROMANCZUK, HELEN;ARMENTANO, DONNA;O'RIORDAN, CATHERINE, R. |
分类号 |
C12N15/09;A61K35/76;A61K38/00;A61K48/00;C07K14/075;C12N7/00;C12N15/34;C12N15/861 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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