<p>A diagnostic or prognostic assay is disclosed for a disease or condition characterised by abnormal methylation of cytosine at a site or sites within the glutathione-S-transferase (GST) Pi gene and/or its regulatory flanking sequences (e.g. prostate cancer and liver cancer). The assay comprises: (i) isolating DNA from said subject, and (ii) determining (e.g. by selective PCR amplification) the presence of abnormal methylation of cytosine at a site or sites within the GST-Pi gene and/or its regulatory flanking sequences.</p>
申请公布号
WO9955905(A1)
申请公布日期
1999.11.04
申请号
WO1999AU00306
申请日期
1999.04.23
申请人
COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION;CLARK, SUSAN, JOY;MILLAR, DOUGLAS, S.;MOLLOY, PETER, LAURENCE