发明名称 |
COMPOSITIONS CONTAINING AN OX-40 RECEPTOR BINDING AGENT OR A NUCLEIC ACID ENCODING THE SAME AND METHODS FOR ENHANCING ANTIGEN-SPECIFIC IMMUNE RESPONSE |
摘要 |
Compositions and methods for enhancing the immune response of a mammal to an antigen by engaging the OX-40 receptor on the surface of T-cells are disclosed, comprising administering to the mammal a composition comprising a purified OX-40 receptor binding agent and a pharmaceutically acceptable carrier, wherein said composition is administered to the mammal such that the OX-40 receptor binding agent is presented to T-cells of the mammal during or shortly after priming of the T-cells by the antigen. Such compositions and methods can be used in immunization and cancer treatment.
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申请公布号 |
WO9942585(A9) |
申请公布日期 |
1999.11.04 |
申请号 |
WO1999US03908 |
申请日期 |
1999.02.23 |
申请人 |
SISTERS OF PROVIDENCE IN OREGON |
发明人 |
WEINBERG, ANDREW, D. |
分类号 |
C12N15/02;A61K38/00;A61K39/00;A61K39/395;A61K48/00;A61P35/00;A61P37/04;C07K14/705;C07K16/28;C12N15/12;(IPC1-7):C12N15/12;A61K38/16 |
主分类号 |
C12N15/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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